Study found that up to 110 years longevity genes

Taiwan's Yang Ming University research team claims to find genes regulating longevity Cisd2 further use of transgenic technology to enhance the amount of longevity gene, so that experiments in mice survived up to 36 months, 1.4 times than normal mice, the equivalent of 110-year-old man. More importantly, these "longevity rat" is still full of energy without the old state. The future, if genetic material to identify additional Cisd2, human beings are expected to live forever, forever green.

　　Mouse gene was found to increase longevity 1.4 times life
Taiwan's Department of Life Science, National Yang Ming University Genome Research Institute, Professor Tsai Ting-fen, a seminar yesterday in old age medicine, published the new findings. Last year, the team found Cisd2 longevity protein gene chromosome, and confirmed that the mice less Cisd2 genes will become "premature aging rats", half life, for the first time cracked the password of biological aging. In the international journal "Genes and Development," was published, much attention.

Tsai Ting-fen, Cisd2 gene protein decreases with age, mitochondria (cellular power plant) damaged, leading to aging; If you can maintain a certain amount, you can slow down muscle and nerve degeneration and enhance the vitality and quality of life in old age.

The new discovery is the use of gene transfer technology, increase the amount of five mice into Cisd2 protein, tracking transgenic mice 36 months 80% still alive, compared with normal mice survived an average of 24-26 months, 1.4 times full life.

Conversion of adult classes, the average life expectancy of women in Taiwan 80 years old, is expected to be extended to the next 112 years. Tsai Ting-fen said that in general the amount of old mice Cisd2 protein will decline to 30% at birth, but the longevity of transgenic mice because of added protein, the body is still 80% of the longevity gene activity. So be smart and lively and lovely performance, muscle strength tests do not lose the prime of life, as young mice, the response was curious about new things, not a bit lightly.

Yangming research team used last year againstOxygenMice Cisd2 agent to enhance the activity of metabolic functions better. Generally only 7-8 month-old male fertility, but the activity of mice for 12 months is also good for female fertility, energetic.

Tsai Ting-fen, human longevity gene protein rapid decline in middle age, women after menopause, the most significant decline, if add anti-aging drugs, to maintain longevity gene activity not only prolong life, physical activity is maintained in the prime of life like Wang; this The next step will be the body of white blood cell experiments.

　　Drugs Prolonging Life, "still a long way" to solve difficult social problems
Chairman of the Taiwan Geriatrics Society Ching-Yu Chen, Chen-Hsen Lee Yang-Ming University School of Medicine Dean of the study are positive, but also questioned if man live forever in the world be like? Yangming team found that the key to longevity genes, affirmed the medical community , but really to find drugs to extend life, there is a great long way to go.

Taipei Veterans General Hospital Medical Center, senior citizens, said Christine Ren Chenliang, Veterans General Hospital, National Yang Ming will participate in the study, understanding the association with longevity and aging mechanisms. The current studies are animal experiments, to find new drugs to regulate longevity gene composition, to the clinical market, "there is a long way," and the application of the future should be the way to regulate gene activity after birth, the medical ethical debate is not over .

Liang-Kung Chen believes that as human life expectancy, the impact of the social, cultural, Europe, many wealthy people spend lots of money to do all kinds of anti-aging treatment, suggesting that could live to 120 years old. 65-year-old retired people today, if everyone lived to 120 years old, on government finance and the social resources will be a heavy burden.